No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
76136 |
4. Check minimum number of eventsNone |
76136 |
5. Include endpointsNone |
76136 |
6. Filter based on genotype QC (FinnGen only) |
73410 |
Control definitions (FinnGen only)
Control exclude
H7_LENS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H25-H28
Name in latin
Cataracta senilis
Senile cataract
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 769508 | 478505 | 285296 |
| Only index persons | 638614 | 403216 | 235398 |
| Unadjusted period prevalence (%) | |||
| Whole population | 11.52 | 13.71 | 7.97 |
| Only index persons | 12.67 | 14.82 | 8.99 |
| Median age at first event (years) | |||
| Whole population | 74.89 | 75.33 | 74.16 |
| Only index persons | 74.46 | 74.89 | 73.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 73410 | 39164 | 34246 |
| Unadjusted period prevalence (%) | 16.23 | 15.38 | 17.20 |
| Median age at first event (years) | 72.90 | 72.42 | 73.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_CATARACTSENILE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CATARACTSENILE | 0.958 [0.89, 1.03] | 0.224 |
| Birth year | 0.996 [0.99, 1.0] | 0.275 |
During the follow-up period (1.1.1998 — 31.12.2019), 142763 out of 364894 females with H7_CATARACTSENILE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CATARACTSENILE | 1.198 [1.1, 1.31] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 93237 out of 216465 males with H7_CATARACTSENILE died.
Mortality risk
Mortality risk for people of age
years, who have H7_CATARACTSENILE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.169% |
| 5 | 0.445% | 0.996% |
| 10 | 1.159% | 2.529% |
| 15 | 2.215% | 4.579% |
| 20 | 3.926% | 7.595% |
Relationships between endpoints
↥Index endpoint: H7_CATARACTSENILE – Senile cataract
GWS hits: 48
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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