Aphakia

H7_APHAKIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H27.0
  • Hospital discharge: ICD-9 3793A
  • Hospital discharge: ICD-8 37872
  • Cause of death: ICD-10 H27.0
  • Cause of death: ICD-9 3793A
  • Cause of death: ICD-8 37872

2 out of 7 registries used, show all original rules.

576

4. Check minimum number of events

None

576

5. Include endpoints

None

576

6. Filter based on genotype QC (FinnGen only)

550

Control definitions (FinnGen only)

Control exclude H7_LENS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H27
Name in latin Aphakia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10286 5262 4814
Only index persons 5128 2468 2660
Unadjusted period prevalence (%)
Whole population 0.14 0.15 0.13
Only index persons 0.10 0.09 0.10
Median age at first event (years)
Whole population 63.75 67.32 59.82
Only index persons 53.87 59.58 48.57

-FinnGen-

Key figures

All Female Male
Number of individuals 550 200 350
Unadjusted period prevalence (%) 0.14 0.08 0.18
Median age at first event (years) 55.56 54.30 56.29

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint H7_APHAKIA and mortality.

Females

Parameter HR [95% CI] p-value
H7_APHAKIA 1.166 [1.01, 1.34] 0.033
Birth year 0.994 [0.99, 1.0] 0.218

During the follow-up period (1.1.1998 — 31.12.2019), 474 out of 1272 females with H7_APHAKIA died.

Males

Parameter HR [95% CI] p-value
H7_APHAKIA 1.201 [1.03, 1.4] 0.021
Birth year 0.985 [0.97, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 451 out of 1466 males with H7_APHAKIA died.

Mortality risk

Mortality risk for people of age

years, who have H7_APHAKIA.

N-year risk Females Males
1 0.09% 0.206%
5 0.591% 1.283%
10 1.564% 3.269%
15 2.999% 6.2%
20 5.598% 10.411%

Relationships between endpoints

Index endpoint: H7_APHAKIA – Aphakia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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