generalised epilepsy: A chronic condition characterised by recurrent generalised seizures.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
465085 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
842 |
6. Filter based on genotype QC (FinnGen only) |
800 |
Control definitions (FinnGen only)
Control exclude
G6_EPLEPSY
Control conditions
not FE
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Generalized epilepsy, strict definition
based on the number of shared cases.
Similar with more cases:
- Generalized epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13436 | 6594 | 6672 |
| Only index persons | 9660 | 5220 | 4440 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.19 | 0.19 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 26.02 | 23.13 | 28.07 |
| Only index persons | 19.95 | 20.03 | 19.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 800 | 493 | 307 |
| Unadjusted period prevalence (%) | 0.18 | 0.19 | 0.15 |
| Median age at first event (years) | 25.34 | 23.47 | 28.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint GE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 3.042 [2.55, 3.62] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.156 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 3730 females with GE_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| GE_STRICT | 2.983 [2.53, 3.52] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 387 out of 3234 males with GE_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have GE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.259% | 0.522% |
| 5 | 1.7% | 3.308% |
| 10 | 4.063% | 8.705% |
| 15 | 8.056% | 15.884% |
| 20 | 14.044% | 25.461% |
Relationships between endpoints
↥Index endpoint: GE_STRICT – Generalized epilepsy, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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