quadriplegia: Paralysis of all four limbs. [database_cross_reference: NCIT:P378]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
230 |
4. Check minimum number of eventsNone |
230 |
5. Include endpointsNone |
230 |
6. Filter based on genotype QC (FinnGen only) |
222 |
Control definitions (FinnGen only)
Control exclude
G6_CPETAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Tetraplegia
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4087 | 1500 | 2554 |
| Only index persons | 3242 | 1232 | 2010 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.07 |
| Only index persons | 0.06 | 0.05 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 50.34 | 49.30 | 50.77 |
| Only index persons | 48.83 | 47.36 | 49.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 222 | 86 | 136 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.07 |
| Median age at first event (years) | 53.01 | 43.94 | 58.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_TETRAPLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TETRAPLE | 4.524 [3.57, 5.73] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.319 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1131 females with G6_TETRAPLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TETRAPLE | 4.224 [3.6, 4.96] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 782 out of 1973 males with G6_TETRAPLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_TETRAPLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.438% | 0.861% |
| 5 | 2.374% | 5.06% |
| 10 | 6.461% | 12.798% |
| 15 | 11.992% | 21.439% |
| 20 | 20.747% | 34.276% |
Relationships between endpoints
↥Index endpoint: G6_TETRAPLE – Tetraplegia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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