status epilepticus: Status epilepticus is defined as a continuous seizure lasting more than 30 min, or two or more seizures without full recovery of consciousness between any of them.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1283 |
4. Check minimum number of eventsNone |
1283 |
5. Include endpointsNone |
1283 |
6. Filter based on genotype QC (FinnGen only) |
1235 |
Control definitions (FinnGen only)
Control exclude
G6_EPIPAROX
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G40-G47
Name in latin
Status epilepticus
Similar endpoints
↥List of similar endpoints to
Status epilepticus
based on the number of shared cases.
Similar with more cases:
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16312 | 7475 | 8685 |
| Only index persons | 12694 | 6020 | 6674 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.23 | 0.21 | 0.24 |
| Only index persons | 0.24 | 0.22 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 58.08 | 59.36 | 56.83 |
| Only index persons | 58.42 | 59.57 | 57.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1235 | 557 | 678 |
| Unadjusted period prevalence (%) | 0.29 | 0.22 | 0.34 |
| Median age at first event (years) | 58.35 | 54.28 | 61.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_STATUSEPI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_STATUSEPI | 5.233 [4.4, 6.23] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.205 |
During the follow-up period (1.1.1998 — 31.12.2019), 2011 out of 4852 females with G6_STATUSEPI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_STATUSEPI | 5.675 [4.84, 6.66] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 2659 out of 5690 males with G6_STATUSEPI died.
Mortality risk
Mortality risk for people of age
years, who have G6_STATUSEPI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.468% | 1.096% |
| 5 | 2.941% | 5.976% |
| 10 | 7.489% | 14.464% |
| 15 | 14.532% | 25.265% |
| 20 | 23.537% | 40.207% |
Relationships between endpoints
↥Index endpoint: G6_STATUSEPI – Status epilepticus
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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