peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
194 |
4. Check minimum number of eventsNone |
194 |
5. Include endpointsNone |
194 |
6. Filter based on genotype QC (FinnGen only) |
188 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G60-G64
Name in latin
Aliae morbositates systematis nervosi peripherici
Similar endpoints
↥List of similar endpoints to
Other disorders of peripheral nervous system
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1252 | 584 | 661 |
| Only index persons | 1109 | 536 | 573 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 59.48 | 59.38 | 59.73 |
| Only index persons | 57.53 | 58.02 | 57.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 188 | 101 | 87 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 58.49 | 56.24 | 61.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_PERIPHOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PERIPHOTH | 1.811 [1.42, 2.32] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 143 out of 508 females with G6_PERIPHOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PERIPHOTH | 2.226 [1.7, 2.91] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 563 males with G6_PERIPHOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_PERIPHOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.178% | 0.322% |
| 5 | 0.962% | 2.451% |
| 10 | 2.551% | 6.395% |
| 15 | 4.571% | 12.048% |
| 20 | 7.489% | 19.046% |
Relationships between endpoints
↥Index endpoint: G6_PERIPHOTH – Other disorders of peripheral nervous system
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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