paraplegia: Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord. [database_cross_reference: NCIT:P378]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
734 |
4. Check minimum number of eventsNone |
734 |
5. Include endpointsNone |
734 |
6. Filter based on genotype QC (FinnGen only) |
712 |
Control definitions (FinnGen only)
Control exclude
G6_CPETAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Paraplegia, diplegia of upper limbs
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7688 | 3418 | 4167 |
| Only index persons | 6093 | 2826 | 3267 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.10 | 0.12 |
| Only index persons | 0.12 | 0.10 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 56.92 | 57.26 | 56.41 |
| Only index persons | 54.02 | 54.33 | 53.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 712 | 321 | 391 |
| Unadjusted period prevalence (%) | 0.16 | 0.13 | 0.20 |
| Median age at first event (years) | 53.76 | 47.33 | 59.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_PARDIPLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARDIPLE | 3.284 [2.85, 3.78] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 1018 out of 2755 females with G6_PARDIPLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_PARDIPLE | 3.353 [2.93, 3.84] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1463 out of 3289 males with G6_PARDIPLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_PARDIPLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.544% |
| 5 | 1.408% | 3.501% |
| 10 | 3.74% | 7.817% |
| 15 | 7.163% | 14.977% |
| 20 | 12.565% | 24.983% |
Relationships between endpoints
↥Index endpoint: G6_PARDIPLE – Paraplegia, diplegia of upper limbs
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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