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Other and unspecified paralytic syndromes

EFO MESH Endpoint Browser PheWeb

G6_PARALOTHUNS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G83.8, G83.9
  • Hospital discharge: ICD-9 — 344
  • Hospital discharge: ICD-8 — 3440[8-9]
  • Cause of death: ICD-10 — G83.8, G83.9
  • Cause of death: ICD-9 — 344
  • Cause of death: ICD-8 — 3440[8-9]

2 out of 7 registries used, show all original rules.

455

4. Check minimum number of events

None

455

5. Include endpoints

None

455

6. Filter based on genotype QC (FinnGen only)

436

Control definitions (FinnGen only)

Control exclude G6_CPETAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5694 2528 3080
Only index persons 4141 1913 2228
Unadjusted period prevalence (%)
Whole population 0.08 0.07 0.09
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 46.76 48.42 45.00
Only index persons 38.07 42.26 34.48

-FinnGen-

Key figures

All Female Male
Number of individuals 436 231 205
Unadjusted period prevalence (%) 0.10 0.09 0.10
Median age at first event (years) 46.76 42.74 51.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint G6_PARALOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_PARALOTHUNS 2.863 [2.26, 3.63] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 320 out of 1060 females with G6_PARALOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_PARALOTHUNS 2.83 [2.28, 3.52] < 0.001
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 413 out of 1080 males with G6_PARALOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_PARALOTHUNS.

N-year risk Females Males
1 0.199% 0.461%
5 1.319% 3.017%
10 3.301% 7.971%
15 6.249% 14.537%
20 10.48% 24.181%

Relationships between endpoints

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Index endpoint: G6_PARALOTHUNS – Other and unspecified paralytic syndromes

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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