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This is a non-core endpoint: only basic statistics are computed.

Myopathy due to other toxic agents

G6_MYOPTOX

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G72.2
  • Hospital discharge: ICD-9 3594A
  • Cause of death: ICD-10 G72.2
  • Cause of death: ICD-9 3594A

2 out of 7 registries used, show all original rules.

17

4. Check minimum number of events

None

17

5. Include endpoints

None

17

6. Filter based on genotype QC (FinnGen only)

16

Control definitions (FinnGen only)

Control exclude G6_MYONEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G72
Name in latin Myopathia toxica (non alcoholica)

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 243 92 150
Only index persons 196 81 115
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 63.76 68.85 60.64
Only index persons 63.00 68.10 59.40

-FinnGen-

Key figures

All Female Male
Number of individuals 16 6 10
Unadjusted period prevalence (%) 0.00 0.00 0.01
Median age at first event (years) 60.22 64.20 57.83

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint G6_MYOPTOX and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
G6_MYOPTOX 4.005 [1.69, 9.49] 0.002
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 129 males with G6_MYOPTOX died.

Mortality risk

Mortality risk for people of age

years, who have G6_MYOPTOX.

N-year risk Females Males
1 No data 0.809%
5 No data 4.477%
10 No data 11.36%
15 No data 21.072%
20 No data 33.822%

Relationships between endpoints

Index endpoint: G6_MYOPTOX – Myopathy due to other toxic agents

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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