No definition available.
Disorders of myoneural junction and muscle in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
G6_MYOMUSCINOTH
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
247 |
4. Check minimum number of eventsNone |
247 |
5. Include endpointsNone |
247 |
6. Filter based on genotype QC (FinnGen only) |
235 |
Control definitions (FinnGen only)
Control exclude
G6_MYONEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorders of myoneural junction and muscle in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1357 | 973 | 377 |
| Only index persons | 1184 | 865 | 319 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 61.99 | 62.44 | 60.81 |
| Only index persons | 61.00 | 61.15 | 60.58 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 235 | 174 | 61 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.03 |
| Median age at first event (years) | 56.87 | 55.63 | 60.40 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MYOMUSCINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYOMUSCINOTH | 2.496 [2.04, 3.06] | < 0.001 |
| Birth year | 1.002 [0.99, 1.01] | 0.715 |
During the follow-up period (1.1.1998 — 31.12.2019), 313 out of 874 females with G6_MYOMUSCINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MYOMUSCINOTH | 2.303 [1.64, 3.22] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 124 out of 312 males with G6_MYOMUSCINOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_MYOMUSCINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.284% | 0.376% |
| 5 | 1.534% | 2.586% |
| 10 | 3.878% | 6.089% |
| 15 | 7.889% | 11.542% |
| 20 | 14.235% | 18.932% |
Relationships between endpoints
↥Index endpoint: G6_MYOMUSCINOTH – Disorders of myoneural junction and muscle in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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