No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
242 |
4. Check minimum number of eventsNone |
242 |
5. Include endpointsNone |
242 |
6. Filter based on genotype QC (FinnGen only) |
230 |
Control definitions (FinnGen only)
Control exclude
G6_MYONEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified primary disorders of muscles
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1716 | 804 | 901 |
| Only index persons | 1507 | 719 | 788 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 51.52 | 52.43 | 50.70 |
| Only index persons | 51.61 | 52.14 | 51.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 230 | 118 | 112 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 52.28 | 52.73 | 51.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MUSCOTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MUSCOTHUNS | 2.962 [2.19, 4.0] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 136 out of 719 females with G6_MUSCOTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MUSCOTHUNS | 2.651 [2.11, 3.34] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 773 males with G6_MUSCOTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MUSCOTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.384% |
| 5 | 1.66% | 2.69% |
| 10 | 3.948% | 6.826% |
| 15 | 7.418% | 13.381% |
| 20 | 12.42% | 22.845% |
Relationships between endpoints
↥Index endpoint: G6_MUSCOTHUNS – Other and unspecified primary disorders of muscles
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data