cycloplegia: Cycloplegia is paralysis of the ciliary muscle of the eye, resulting in a loss of accommodation.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
477 |
4. Check minimum number of eventsNone |
477 |
5. Include endpointsNone |
477 |
6. Filter based on genotype QC (FinnGen only) |
461 |
Control definitions (FinnGen only)
Control exclude
G6_CPETAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Monoplegia
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3782 | 1832 | 1917 |
| Only index persons | 3338 | 1651 | 1687 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.05 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 57.60 | 56.77 | 58.25 |
| Only index persons | 56.05 | 55.02 | 57.06 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 461 | 259 | 202 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | 57.22 | 54.03 | 61.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MONOPLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOPLE | 2.189 [1.82, 2.63] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.326 |
During the follow-up period (1.1.1998 — 31.12.2019), 462 out of 1605 females with G6_MONOPLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MONOPLE | 2.165 [1.83, 2.56] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 563 out of 1664 males with G6_MONOPLE died.
Mortality risk
Mortality risk for people of age
years, who have G6_MONOPLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.199% | 0.476% |
| 5 | 1.338% | 2.423% |
| 10 | 3.21% | 5.915% |
| 15 | 6.149% | 11.001% |
| 20 | 10.489% | 18.359% |
Relationships between endpoints
↥Index endpoint: G6_MONOPLE – Monoplegia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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