No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
130 |
4. Check minimum number of eventsNone |
130 |
5. Include endpointsNone |
130 |
6. Filter based on genotype QC (FinnGen only) |
124 |
Control definitions (FinnGen only)
Control exclude
G6_MYONEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G71
Name in latin
Myopathia mitochondrialis non alibi classificata
Similar endpoints
↥List of similar endpoints to
Mitochondrial myopathy
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 856 | 465 | 387 |
| Only index persons | 696 | 388 | 308 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 46.83 | 50.41 | 42.39 |
| Only index persons | 46.69 | 49.89 | 42.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 124 | 77 | 47 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 48.67 | 48.68 | 48.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_MITOCMY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MITOCMY | 4.998 [3.54, 7.06] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 104 out of 373 females with G6_MITOCMY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MITOCMY | 4.33 [2.96, 6.34] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 317 males with G6_MITOCMY died.
Mortality risk
Mortality risk for people of age
years, who have G6_MITOCMY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.585% | 0.899% |
| 5 | 3.166% | 5.188% |
| 10 | 7.96% | 12.612% |
| 15 | 13.614% | 22.547% |
| 20 | 22.641% | 35.342% |
Relationships between endpoints
↥Index endpoint: G6_MITOCMY – Mitochondrial myopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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