No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
134 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified neuropathies
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1396 | 595 | 779 |
| Only index persons | 972 | 439 | 533 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 55.99 | 55.26 | 56.05 |
| Only index persons | 49.86 | 48.73 | 50.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 134 | 60 | 74 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 52.62 | 46.92 | 57.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_HERIPOTHUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.949 [1.41, 2.69] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.339 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 327 females with G6_HERIPOTHUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HERIPOTHUN | 1.706 [1.3, 2.23] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 92 out of 395 males with G6_HERIPOTHUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_HERIPOTHUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.17% | 0.291% |
| 5 | 1.14% | 2.114% |
| 10 | 2.679% | 5.458% |
| 15 | 5.451% | 10.265% |
| 20 | 9.551% | 16.625% |
Relationships between endpoints
↥Index endpoint: G6_HERIPOTHUN – Other and unspecified neuropathies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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