≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Hemiplegia

DOID EFO Endpoint Browser PheWeb

G6_HEMIPLE

hemiplegia: Severe or complete loss of motor function on one side of the body. This condition is usually caused by brain diseases that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, brain stem lesions; cervical spinal cord diseases; peripheral nervous system diseases; and other conditions may manifest as hemiplegia. The term hemiparesis (see paresis) refers to mild to moderate weakness involving one side of the body. [ MESH:D006429 ]

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G81
  • Hospital discharge: ICD-9 — 342
  • Hospital discharge: ICD-8 — 34400
  • Cause of death: ICD-10 — G81
  • Cause of death: ICD-9 — 342
  • Cause of death: ICD-8 — 34400

2 out of 7 registries used, show all original rules.

1924

4. Check minimum number of events

None

1924

5. Include endpoints

None

1924

6. Filter based on genotype QC (FinnGen only)

1852

Control definitions (FinnGen only)

Control exclude G6_CPETAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G80-G83
Name in latin Hemiplegia

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 26668 13097 13007
Only index persons 15147 8058 7089
Unadjusted period prevalence (%)
Whole population 0.37 0.38 0.36
Only index persons 0.28 0.30 0.27
Median age at first event (years)
Whole population 62.63 63.06 61.95
Only index persons 52.30 51.17 53.58

-FinnGen-

Key figures

All Female Male
Number of individuals 1852 984 868
Unadjusted period prevalence (%) 0.41 0.39 0.44
Median age at first event (years) 52.79 46.59 59.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HEMIPLE and mortality.

Females

Parameter HR [95% CI] p-value
G6_HEMIPLE 2.657 [2.41, 2.93] < 0.001
Birth year 0.995 [0.99, 1.0] 0.197

During the follow-up period (1.1.1998 — 31.12.2019), 2893 out of 7556 females with G6_HEMIPLE died.

Males

Parameter HR [95% CI] p-value
G6_HEMIPLE 2.42 [2.19, 2.68] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 3188 out of 6891 males with G6_HEMIPLE died.

Mortality risk

Mortality risk for people of age

years, who have G6_HEMIPLE.

N-year risk Females Males
1 0.253% 0.489%
5 1.566% 2.915%
10 3.809% 6.952%
15 7.185% 13.236%
20 12.133% 21.79%

Relationships between endpoints

↥

Index endpoint: G6_HEMIPLE – Hemiplegia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data