Guillain-Barre syndrome: Guillain-BarrC) syndrome (GBS) is the term used to describe a spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS; see these terms) and some other regional variants.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
510 |
4. Check minimum number of eventsNone |
510 |
5. Include endpointsNone |
510 |
6. Filter based on genotype QC (FinnGen only) |
489 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G61
Name in latin
Syndroma Guillain-Barré
Similar endpoints
↥List of similar endpoints to
Guillain-Barre syndrome
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4635 | 2063 | 2535 |
| Only index persons | 3894 | 1777 | 2117 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.07 |
| Only index persons | 0.07 | 0.07 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 50.92 | 49.00 | 52.39 |
| Only index persons | 48.14 | 46.19 | 49.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 489 | 223 | 266 |
| Unadjusted period prevalence (%) | 0.11 | 0.09 | 0.13 |
| Median age at first event (years) | 51.52 | 48.16 | 54.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_GUILBAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_GUILBAR | 2.186 [1.81, 2.63] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.473 |
During the follow-up period (1.1.1998 — 31.12.2019), 256 out of 1332 females with G6_GUILBAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_GUILBAR | 1.876 [1.59, 2.21] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 391 out of 1622 males with G6_GUILBAR died.
Mortality risk
Mortality risk for people of age
years, who have G6_GUILBAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.24% | 0.382% |
| 5 | 1.313% | 1.977% |
| 10 | 3.35% | 4.535% |
| 15 | 6.366% | 8.683% |
| 20 | 11.367% | 14.611% |
Relationships between endpoints
↥Index endpoint: G6_GUILBAR – Guillain-Barre syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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