Drug-induced polyneuropathy

G6_DRUGPOLY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G62.0#
  • Hospital discharge: ICD-9 3576
  • Cause of death: ICD-10 G62.0#
  • Cause of death: ICD-9 3576

2 out of 7 registries used, show all original rules.

266

4. Check minimum number of events

None

266

5. Include endpoints

None

266

6. Filter based on genotype QC (FinnGen only)

251

Control definitions (FinnGen only)

Control exclude G6_POLYNEU

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G62
Name in latin Polyneuropathia medicamento provocata

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1549 841 700
Only index persons 1345 745 600
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 62.86 64.41 60.97
Only index persons 63.08 64.55 61.25

-FinnGen-

Key figures

All Female Male
Number of individuals 251 136 115
Unadjusted period prevalence (%) 0.06 0.05 0.06
Median age at first event (years) 62.53 63.58 61.28

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint G6_DRUGPOLY and mortality.

Females

Parameter HR [95% CI] p-value
G6_DRUGPOLY 4.185 [3.26, 5.37] < 0.001
Birth year 0.996 [0.98, 1.01] 0.502

During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 698 females with G6_DRUGPOLY died.

Males

Parameter HR [95% CI] p-value
G6_DRUGPOLY 2.961 [2.28, 3.84] < 0.001
Birth year 0.99 [0.98, 1.0] 0.032

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 581 males with G6_DRUGPOLY died.

Mortality risk

Mortality risk for people of age

years, who have G6_DRUGPOLY.

N-year risk Females Males
1 0.486% 0.586%
5 2.514% 3.499%
10 6.052% 8.655%
15 11.118% 16.382%
20 19.482% 27.032%

Relationships between endpoints

Index endpoint: G6_DRUGPOLY – Drug-induced polyneuropathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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