No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
266 |
4. Check minimum number of eventsNone |
266 |
5. Include endpointsNone |
266 |
6. Filter based on genotype QC (FinnGen only) |
251 |
Control definitions (FinnGen only)
Control exclude
G6_POLYNEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G62
Name in latin
Polyneuropathia medicamento provocata
Similar endpoints
↥List of similar endpoints to
Drug-induced polyneuropathy
based on the number of shared cases.
Similar with more cases:
- Polyneuropathies and other disorders of the peripheral nervous system
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1549 | 841 | 700 |
| Only index persons | 1345 | 745 | 600 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 62.86 | 64.41 | 60.97 |
| Only index persons | 63.08 | 64.55 | 61.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 251 | 136 | 115 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | 62.53 | 63.58 | 61.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_DRUGPOLY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGPOLY | 4.185 [3.26, 5.37] | < 0.001 |
| Birth year | 0.996 [0.98, 1.01] | 0.502 |
During the follow-up period (1.1.1998 — 31.12.2019), 289 out of 698 females with G6_DRUGPOLY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGPOLY | 2.961 [2.28, 3.84] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.032 |
During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 581 males with G6_DRUGPOLY died.
Mortality risk
Mortality risk for people of age
years, who have G6_DRUGPOLY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.486% | 0.586% |
| 5 | 2.514% | 3.499% |
| 10 | 6.052% | 8.655% |
| 15 | 11.118% | 16.382% |
| 20 | 19.482% | 27.032% |
Relationships between endpoints
↥Index endpoint: G6_DRUGPOLY – Drug-induced polyneuropathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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