muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
93 |
4. Check minimum number of eventsNone |
93 |
5. Include endpointsNone |
93 |
6. Filter based on genotype QC (FinnGen only) |
90 |
Control definitions (FinnGen only)
Control exclude
G6_MYONEU
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G72
Name in latin
Myopathia medicamento provocata
Similar endpoints
↥List of similar endpoints to
Drug-induced myopathy
based on the number of shared cases.
Similar with more cases:
- Diseases of the myoneural junction and muscle
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1105 | 444 | 652 |
| Only index persons | 966 | 397 | 569 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.92 | 70.20 | 61.21 |
| Only index persons | 64.72 | 69.67 | 61.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 90 | 36 | 54 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 63.95 | 59.10 | 67.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_DRUGMYOP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGMYOP | 2.524 [1.94, 3.28] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.681 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 406 females with G6_DRUGMYOP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DRUGMYOP | 3.526 [2.43, 5.11] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 603 males with G6_DRUGMYOP died.
Mortality risk
Mortality risk for people of age
years, who have G6_DRUGMYOP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.338% | 0.656% |
| 5 | 1.617% | 3.793% |
| 10 | 4.124% | 9.144% |
| 15 | 7.844% | 16.717% |
| 20 | 13.534% | 27.041% |
Relationships between endpoints
↥Index endpoint: G6_DRUGMYOP – Drug-induced myopathy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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