cerebral palsy: A group of disorders affecting the development of movement and posture, often accompanied by disturbances of sensation, perception, cognition, and behavior. It results from damage to the fetal or infant brain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
611 |
4. Check minimum number of eventsNone |
611 |
5. Include endpointsNone |
611 |
6. Filter based on genotype QC (FinnGen only) |
574 |
Control definitions (FinnGen only)
Control exclude
G6_CPETAL
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G80-G83
Name in latin
Paralysis cerebralis infantilis
Similar endpoints
↥List of similar endpoints to
Cerebral palsy
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13423 | 5771 | 7608 |
| Only index persons | 10731 | 4719 | 6012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.19 | 0.17 | 0.21 |
| Only index persons | 0.20 | 0.17 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 4.66 | 4.71 | 4.29 |
| Only index persons | 4.37 | 4.68 | 4.12 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 574 | 299 | 275 |
| Unadjusted period prevalence (%) | 0.13 | 0.12 | 0.14 |
| Median age at first event (years) | 5.47 | 5.92 | 4.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint G6_CP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CP | 3.963 [3.08, 5.1] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.391 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 2065 females with G6_CP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CP | 4.157 [3.3, 5.24] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 321 out of 2713 males with G6_CP died.
Mortality risk
Mortality risk for people of age
years, who have G6_CP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.503% | 0.856% |
| 5 | 2.212% | 4.649% |
| 10 | 5.788% | 11.035% |
| 15 | 11.207% | 20.602% |
| 20 | 18.459% | 32.662% |
Relationships between endpoints
↥Index endpoint: G6_CP – Cerebral palsy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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