No definition available.
Cluster headache, strict, including avohilmo
G6_CLUSTHEADACHE_STRICT_INCLAVO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
797 |
4. Check minimum number of eventsNone |
797 |
5. Include endpoints |
1703 |
6. Filter based on genotype QC (FinnGen only) |
1633 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6
Cluster headache, strict, including avohilmo
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11512 | 5294 | 6127 |
| Only index persons | 11219 | 5224 | 5995 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.15 | 0.17 |
| Only index persons | 0.21 | 0.19 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 41.46 | 42.16 | 40.92 |
| Only index persons | 41.26 | 42.00 | 40.63 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1633 | 995 | 638 |
| Unadjusted period prevalence (%) | 0.36 | 0.39 | 0.32 |
| Median age at first event (years) | 45.91 | 44.17 | 48.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_CLUSTHEADACHE_STRICT_INCLAVO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CLUSTHEADACHE_STRICT_INCLAVO | 0.92 [0.76, 1.12] | 0.401 |
| Birth year | 0.992 [0.98, 1.0] | 0.079 |
During the follow-up period (1.1.1998 — 31.12.2019), 184 out of 4534 females with G6_CLUSTHEADACHE_STRICT_INCLAVO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CLUSTHEADACHE_STRICT_INCLAVO | 1.18 [1.02, 1.36] | 0.022 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 377 out of 5156 males with G6_CLUSTHEADACHE_STRICT_INCLAVO died.
Mortality risk
Mortality risk for people of age
years, who have G6_CLUSTHEADACHE_STRICT_INCLAVO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.061% | 0.231% |
| 5 | 0.422% | 1.241% |
| 10 | 1.148% | 3.496% |
| 15 | 2.343% | 6.482% |
| 20 | 4.264% | 10.817% |
Relationships between endpoints
↥Index endpoint: G6_CLUSTHEADACHE_STRICT_INCLAVO – Cluster headache, strict, including avohilmo
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data