Cauda equina syndrome: Cauda equina syndrome refers to a group of symptoms that occur when some of the nerves in the cauda equina (the bundle of nerves that spread out from the bottom of the spinal cord) become compressed and/or damaged. Signs and symptoms of this condition include pain, numbness, or tingling in the lower back and/or legs; ' foot drop '; problems with bowel and/or bladder control; and sexual dysfunction. Cauda equina syndrome may be caused by a herniated disk , tumor , infection, fracture, or spinal stenosis . Treatment usually targets the underlying cause of the condition and often includes surgery to remove the material that is pressing on the nerves. Physical therapy , occupational therapy , and/or other services may be required if symptoms persist following surgery.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
395 |
4. Check minimum number of eventsNone |
395 |
5. Include endpointsNone |
395 |
6. Filter based on genotype QC (FinnGen only) |
374 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Cauda equina syndrome
based on the number of shared cases.
Similar with more cases:
- Cerebral palsy and other paralytic syndromes
- Neurological diseases
- Neurological diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3048 | 1653 | 1377 |
| Only index persons | 2805 | 1572 | 1233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 54.69 | 54.54 | 54.67 |
| Only index persons | 53.39 | 53.76 | 52.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 374 | 235 | 139 |
| Unadjusted period prevalence (%) | 0.08 | 0.09 | 0.07 |
| Median age at first event (years) | 51.68 | 48.66 | 56.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_CAUDA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUDA | 1.674 [1.35, 2.08] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.302 |
During the follow-up period (1.1.1998 — 31.12.2019), 270 out of 1360 females with G6_CAUDA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_CAUDA | 2.282 [1.82, 2.85] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 1078 males with G6_CAUDA died.
Mortality risk
Mortality risk for people of age
years, who have G6_CAUDA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.116% | 0.472% |
| 5 | 0.849% | 2.728% |
| 10 | 2.433% | 6.745% |
| 15 | 5.003% | 13.023% |
| 20 | 8.671% | 21.312% |
Relationships between endpoints
↥Index endpoint: G6_CAUDA – Cauda equina syndrome
GWS hits: -
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