partial epilepsy: A seizure caused by a localized disorder.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
472066 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
7823 |
6. Filter based on genotype QC (FinnGen only) |
7555 |
Control definitions (FinnGen only)
Control exclude
G6_EPLEPSY
Control conditions
not GE
Extra metadata
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Focal epilepsy, strict definition
based on the number of shared cases.
Similar with more cases:
- Focal epilepsy
- Epilepsy
- Episodal and paroxysmal disorders
- Neurological diseases
- Neurological diseases
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 83361 | 38369 | 44332 |
| Only index persons | 69676 | 32994 | 36682 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.17 | 1.10 | 1.24 |
| Only index persons | 1.31 | 1.21 | 1.40 |
| Median age at first event (years) | |||
| Whole population | 53.68 | 53.75 | 53.47 |
| Only index persons | 52.12 | 52.25 | 52.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7555 | 3714 | 3841 |
| Unadjusted period prevalence (%) | 1.70 | 1.46 | 1.93 |
| Median age at first event (years) | 54.15 | 49.63 | 58.51 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FE_STRICT | 3.574 [3.23, 3.96] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.063 |
During the follow-up period (1.1.1998 — 31.12.2019), 9830 out of 29202 females with FE_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FE_STRICT | 3.485 [3.14, 3.87] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 12596 out of 33557 males with FE_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have FE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.289% | 0.634% |
| 5 | 1.789% | 3.581% |
| 10 | 4.845% | 8.1% |
| 15 | 9.14% | 14.981% |
| 20 | 15.75% | 24.808% |
Relationships between endpoints
↥Index endpoint: FE_STRICT – Focal epilepsy, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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