vestibular disease: Pathological processes of the vestibular labyrinth which contains part of the balancing apparatus. Patients with vestibular diseases show instability and are at risk of frequent falls. [database_cross_reference: MESH:D015837]
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
122676 |
4. Check minimum number of eventsNone |
122676 |
5. Include endpointsNone |
122676 |
6. Filter based on genotype QC (FinnGen only) |
118054 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF3
Falls/tendency to fall
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1433862 | 732590 | 694287 |
| Only index persons | 1260084 | 647587 | 612497 |
| Unadjusted period prevalence (%) | |||
| Whole population | 20.15 | 20.98 | 19.40 |
| Only index persons | 23.60 | 23.81 | 23.38 |
| Median age at first event (years) | |||
| Whole population | 52.20 | 59.28 | 44.66 |
| Only index persons | 51.98 | 58.61 | 44.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118054 | 65683 | 52371 |
| Unadjusted period prevalence (%) | 26.02 | 25.80 | 26.30 |
| Median age at first event (years) | 56.88 | 55.99 | 58.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint FALLS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FALLS | 1.899 [1.77, 2.04] | < 0.001 |
| Birth year | 0.982 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 152425 out of 619961 females with FALLS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FALLS | 2.001 [1.84, 2.18] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 108021 out of 588969 males with FALLS died.
Mortality risk
Mortality risk for people of age
years, who have FALLS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | 0.207% |
| 5 | 0.473% | 1.465% |
| 10 | 1.189% | 3.543% |
| 15 | 2.338% | 6.56% |
| 20 | 4.001% | 11.249% |
Relationships between endpoints
↥Index endpoint: FALLS – Falls/tendency to fall
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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