cognitive disorder: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
122 |
4. Check minimum number of eventsNone |
122 |
5. Include endpointsNone |
122 |
6. Filter based on genotype QC (FinnGen only) |
117 |
Control definitions (FinnGen only)
Control exclude
F5_ORGANIC
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F04-F09
Name in latin
Perturbatio mentis organica sive symptomatica non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified organic or symptomatic mental disorder
based on the number of shared cases.
Similar with more cases:
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2094 | 1063 | 995 |
| Only index persons | 1489 | 777 | 712 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 68.08 | 72.57 | 63.10 |
| Only index persons | 64.41 | 69.43 | 58.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 117 | 50 | 67 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 62.91 | 54.87 | 68.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_UNSORG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_UNSORG | 3.123 [2.53, 3.86] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.371 |
During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 887 females with F5_UNSORG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_UNSORG | 3.978 [2.97, 5.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 830 males with F5_UNSORG died.
Mortality risk
Mortality risk for people of age
years, who have F5_UNSORG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.285% | 0.828% |
| 5 | 1.639% | 4.349% |
| 10 | 4.299% | 11.111% |
| 15 | 9.38% | 19.664% |
| 20 | 14.909% | 33.032% |
Relationships between endpoints
↥Index endpoint: F5_UNSORG – Unspecified organic or symptomatic mental disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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