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Personality and behavioural disorders due to brain disease, damage and dysfunction

EFO MESH Endpoint Browser PheWeb

F5_PERSBEHORG

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F07
  • Hospital discharge: ICD-9 — 310
  • Hospital discharge: ICD-8 — 293
  • Cause of death: ICD-10 — F07
  • Cause of death: ICD-9 — 310
  • Cause of death: ICD-8 — 293

2 out of 7 registries used, show all original rules.

512

4. Check minimum number of events

None

512

5. Include endpoints

None

512

6. Filter based on genotype QC (FinnGen only)

491

Control definitions (FinnGen only)

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F04-F09
Name in latin Perturbationes personae et modi se gerendi a morbo, laesione sive dysfunctione cerebri inductae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7855 2589 5124
Only index persons 5216 1732 3484
Unadjusted period prevalence (%)
Whole population 0.12 0.07 0.14
Only index persons 0.11 0.06 0.13
Median age at first event (years)
Whole population 53.93 56.68 52.32
Only index persons 49.75 51.79 48.73

-FinnGen-

Key figures

All Female Male
Number of individuals 491 175 316
Unadjusted period prevalence (%) 0.13 0.07 0.16
Median age at first event (years) 50.17 46.53 52.18

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_PERSBEHORG and mortality.

Females

Parameter HR [95% CI] p-value
F5_PERSBEHORG 3.369 [2.8, 4.05] < 0.001
Birth year 0.998 [0.99, 1.01] 0.593

During the follow-up period (1.1.1998 — 31.12.2019), 534 out of 1449 females with F5_PERSBEHORG died.

Males

Parameter HR [95% CI] p-value
F5_PERSBEHORG 4.112 [3.58, 4.73] < 0.001
Birth year 0.984 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1321 out of 3047 males with F5_PERSBEHORG died.

Mortality risk

Mortality risk for people of age

years, who have F5_PERSBEHORG.

N-year risk Females Males
1 0.306% 0.696%
5 2.45% 4.059%
10 5.875% 10.45%
15 10.264% 18.921%
20 17.597% 30.434%

Relationships between endpoints

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Index endpoint: F5_PERSBEHORG – Personality and behavioural disorders due to brain disease, damage and dysfunction

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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