Kela-code for behavioural disturbances in mental retardation

F5_KELARET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • KELA reimbursements: KELA codes 113

1 out of 7 registries used, show all original rules.

287

4. Check minimum number of events

None

287

5. Include endpoints

None

287

6. Filter based on genotype QC (FinnGen only)

262

Control definitions (FinnGen only)

Control exclude F5_MENTRET

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12361 5572 6725
Only index persons 9845 4324 5521
Unadjusted period prevalence (%)
Whole population 0.17 0.16 0.19
Only index persons 0.19 0.16 0.21
Median age at first event (years)
Whole population 25.49 28.68 22.73
Only index persons 24.12 26.82 22.01

-FinnGen-

Key figures

All Female Male
Number of individuals 262 126 136
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 24.54 26.12 23.08

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint F5_KELARET and mortality.

Females

Parameter HR [95% CI] p-value
F5_KELARET 7.437 [6.07, 9.11] < 0.001
Birth year 0.993 [0.98, 1.0] 0.092

During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1281 females with F5_KELARET died.

Males

Parameter HR [95% CI] p-value
F5_KELARET 4.05 [3.42, 4.8] < 0.001
Birth year 0.987 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2311 males with F5_KELARET died.

Mortality risk

Mortality risk for people of age

years, who have F5_KELARET.

N-year risk Females Males
1 0.86% 0.752%
5 4.271% 4.842%
10 9.845% 11.323%
15 17.928% 20.999%
20 28.931% 33.385%

Relationships between endpoints

Index endpoint: F5_KELARET – Kela-code for behavioural disturbances in mental retardation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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