No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
18029 |
4. Check minimum number of eventsNone |
18029 |
5. Include endpointsNone |
18029 |
6. Filter based on genotype QC (FinnGen only) |
17319 |
Control definitions (FinnGen only)
Control exclude
F5_UNSMENDIS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Kela-code for severe mental illness
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 160458 | 84706 | 74180 |
| Only index persons | 128635 | 68752 | 59883 |
| Unadjusted period prevalence (%) | |||
| Whole population | 2.25 | 2.43 | 2.07 |
| Only index persons | 2.42 | 2.53 | 2.29 |
| Median age at first event (years) | |||
| Whole population | 40.26 | 43.20 | 36.76 |
| Only index persons | 37.95 | 40.70 | 34.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 17319 | 9317 | 8002 |
| Unadjusted period prevalence (%) | 3.83 | 3.66 | 4.02 |
| Median age at first event (years) | 34.14 | 34.47 | 33.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_KELAMENT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELAMENT | 2.122 [1.96, 2.3] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.174 |
During the follow-up period (1.1.1998 — 31.12.2019), 8913 out of 42407 females with F5_KELAMENT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELAMENT | 2.646 [2.43, 2.88] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 8084 out of 39272 males with F5_KELAMENT died.
Mortality risk
Mortality risk for people of age
years, who have F5_KELAMENT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 0.555% |
| 5 | 1.198% | 3.142% |
| 10 | 2.811% | 7.519% |
| 15 | 5.192% | 14.007% |
| 20 | 9.173% | 23.055% |
Relationships between endpoints
↥Index endpoint: F5_KELAMENT – Kela-code for severe mental illness
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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