Delirium, not induced by alcohol and other psychoactive substances

F5_DELIRIUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F05
  • Hospital discharge: ICD-9 2930
  • Hospital discharge: excluded ICD-8 29430
  • Cause of death: ICD-10 F05
  • Cause of death: ICD-9 2930

2 out of 7 registries used, show all original rules.

3963

4. Check minimum number of events

None

3963

5. Include endpoints

None

3963

6. Filter based on genotype QC (FinnGen only)

3827

Control definitions (FinnGen only)

Control exclude F5_ORGANIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F04-F09
Name in latin Delirium non alcoholicum neque ab aliis substantiis psychotropicis inductum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 54207 26368 27338
Only index persons 44201 22051 22150
Unadjusted period prevalence (%)
Whole population 0.76 0.76 0.76
Only index persons 0.83 0.81 0.85
Median age at first event (years)
Whole population 76.29 80.34 72.44
Only index persons 76.25 80.46 72.05

-FinnGen-

Key figures

All Female Male
Number of individuals 3827 1442 2385
Unadjusted period prevalence (%) 0.96 0.57 1.20
Median age at first event (years) 73.82 74.15 73.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint F5_DELIRIUM and mortality.

Females

Parameter HR [95% CI] p-value
F5_DELIRIUM 2.363 [2.1, 2.65] < 0.001
Birth year 0.996 [0.99, 1.0] 0.285

During the follow-up period (1.1.1998 — 31.12.2019), 12804 out of 20946 females with F5_DELIRIUM died.

Males

Parameter HR [95% CI] p-value
F5_DELIRIUM 3.379 [2.93, 3.9] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 12416 out of 20978 males with F5_DELIRIUM died.

Mortality risk

Mortality risk for people of age

years, who have F5_DELIRIUM.

N-year risk Females Males
1 0.266% 0.55%
5 1.503% 3.932%
10 3.302% 9.148%
15 6.108% 17.63%
20 11.126% 28.314%

Relationships between endpoints

Index endpoint: F5_DELIRIUM – Delirium, not induced by alcohol and other psychoactive substances

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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