erectile dysfunction: Persistent or recurrent inability to achieve or to maintain an erection during sexual activity.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditions
|
207823 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
2642 |
4. Check minimum number of events
Min. number of events
3
|
2642 |
5. Include endpointsNone |
2642 |
6. Filter based on genotype QC (FinnGen only) |
2548 |
Control definitions (FinnGen only)
Control conditions
not ERECTILE_EXCLUSION
Extra metadata
First used in FinnGen datafreeze
DF4
Erectile dysfunction
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18178 | - | 18178 |
| Only index persons | 15195 | - | 15195 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.51 | - | 0.51 |
| Only index persons | 0.58 | - | 0.58 |
| Median age at first event (years) | |||
| Whole population | - | - | 61.18 |
| Only index persons | - | - | 60.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2548 | - | 2548 |
| Unadjusted period prevalence (%) | 1.28 | - | 1.28 |
| Median age at first event (years) | 60.90 | - | 60.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ERECTILE_DYSFUNCTION and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ERECTILE_DYSFUNCTION | 0.84 [0.78, 0.9] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.039 |
During the follow-up period (1.1.1998 — 31.12.2019), 2515 out of 10411 males with ERECTILE_DYSFUNCTION died.
Mortality risk
Mortality risk for people of age
years, who have ERECTILE_DYSFUNCTION.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.186% |
| 5 | No data | 0.921% |
| 10 | No data | 2.428% |
| 15 | No data | 4.881% |
| 20 | No data | 8.63% |
Relationships between endpoints
↥Index endpoint: ERECTILE_DYSFUNCTION – Erectile dysfunction
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data