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Volume depletion

DOID EFO Endpoint Browser PheWeb

E4_VOLUME

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E86
  • Hospital discharge: ICD-9 — 2765
  • Hospital discharge: ICD-8 — 7880
  • Cause of death: ICD-10 — E86
  • Cause of death: ICD-9 — 2765
  • Cause of death: ICD-8 — 7880

2 out of 7 registries used, show all original rules.

3440

4. Check minimum number of events

None

3440

5. Include endpoints

None

3440

6. Filter based on genotype QC (FinnGen only)

3318

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Depletio voluminis liquoris

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 44655 24590 19806
Only index persons 37185 20583 16602
Unadjusted period prevalence (%)
Whole population 0.63 0.70 0.55
Only index persons 0.70 0.76 0.63
Median age at first event (years)
Whole population 77.57 81.19 73.09
Only index persons 77.71 81.39 73.15

-FinnGen-

Key figures

All Female Male
Number of individuals 3318 1447 1871
Unadjusted period prevalence (%) 0.78 0.57 0.94
Median age at first event (years) 72.41 71.02 73.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_VOLUME and mortality.

Females

Parameter HR [95% CI] p-value
E4_VOLUME 2.989 [2.56, 3.49] < 0.001
Birth year 0.994 [0.99, 1.0] 0.148

During the follow-up period (1.1.1998 — 31.12.2019), 10523 out of 18446 females with E4_VOLUME died.

Males

Parameter HR [95% CI] p-value
E4_VOLUME 3.723 [3.05, 4.54] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 7499 out of 14569 males with E4_VOLUME died.

Mortality risk

Mortality risk for people of age

years, who have E4_VOLUME.

N-year risk Females Males
1 0.25% 0.576%
5 1.584% 4.141%
10 4.033% 9.338%
15 7.718% 16.64%
20 13.341% 27.523%

Relationships between endpoints

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Index endpoint: E4_VOLUME – Volume depletion

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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