≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Other specified/unspecified nutritional deficiencies

EFO MESH Endpoint Browser PheWeb

E4_NUTRI_DEF_NAS

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E63.8, E63.9, E63.9+I43.2
  • Hospital discharge: ICD-9 — 269[3-9]
  • Hospital discharge: ICD-8 — 2699
  • Hospital discharge: excluded ICD-8 — 26990
  • Cause of death: ICD-10 — E63.8, E63.9, E63.9+I43.2
  • Cause of death: ICD-9 — 269[3-9]
  • Cause of death: ICD-8 — 2699
  • Cause of death: excluded ICD-8 — 26990

2 out of 7 registries used, show all original rules.

248

4. Check minimum number of events

None

248

5. Include endpoints

None

248

6. Filter based on genotype QC (FinnGen only)

236

Control definitions (FinnGen only)

Control exclude E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2818 1684 1106
Only index persons 2159 1300 859
Unadjusted period prevalence (%)
Whole population 0.04 0.05 0.03
Only index persons 0.04 0.05 0.03
Median age at first event (years)
Whole population 33.04 38.23 24.56
Only index persons 25.04 32.24 14.14

-FinnGen-

Key figures

All Female Male
Number of individuals 236 143 93
Unadjusted period prevalence (%) 0.05 0.06 0.05
Median age at first event (years) 25.67 23.09 29.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

↥

Association

Association between endpoint E4_NUTRI_DEF_NAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_NUTRI_DEF_NAS 3.366 [2.28, 4.96] < 0.001
Birth year 0.992 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 230 females with E4_NUTRI_DEF_NAS died.

Males

Parameter HR [95% CI] p-value
E4_NUTRI_DEF_NAS 4.555 [2.46, 8.43] < 0.001
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 157 males with E4_NUTRI_DEF_NAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_NUTRI_DEF_NAS.

N-year risk Females Males
1 0.247% 0.866%
5 1.609% 5.4%
10 4.136% 12.203%
15 8.068% 22.754%
20 14.903% 35.897%

Relationships between endpoints

↥

Index endpoint: E4_NUTRI_DEF_NAS – Other specified/unspecified nutritional deficiencies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data