No definition available.
Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
E4_HYPERURI
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
149 |
4. Check minimum number of eventsNone |
149 |
5. Include endpointsNone |
149 |
6. Filter based on genotype QC (FinnGen only) |
143 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E79
Name in latin
Hyperurichaemia sine symptomatibus arthritidis inflammatoriae sive morbi tophacei
Similar endpoints
↥List of similar endpoints to
Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
based on the number of shared cases.
Similar with more cases:
- Disorders of purine and pyrimidine metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1098 | 486 | 606 |
| Only index persons | 956 | 413 | 543 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 67.61 | 70.73 | 65.06 |
| Only index persons | 65.92 | 68.15 | 64.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 143 | 50 | 93 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 65.57 | 63.19 | 66.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERURI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERURI | 2.552 [1.94, 3.35] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.157 |
During the follow-up period (1.1.1998 — 31.12.2019), 188 out of 407 females with E4_HYPERURI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERURI | 2.743 [1.91, 3.95] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 181 out of 494 males with E4_HYPERURI died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERURI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.478% |
| 5 | 1.103% | 2.974% |
| 10 | 3.035% | 7.543% |
| 15 | 5.976% | 13.46% |
| 20 | 10.95% | 22.07% |
Relationships between endpoints
↥Index endpoint: E4_HYPERURI – Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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