No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
89 |
4. Check minimum number of eventsNone |
89 |
5. Include endpoints |
107 |
6. Filter based on genotype QC (FinnGen only) |
100 |
Control definitions (FinnGen only)
Control exclude
E4_OBESITY_HYPER
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other hyperalimentation
based on the number of shared cases.
Similar with more cases:
- Obesity and other hyperalimentation
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 767 | 460 | 298 |
| Only index persons | 615 | 384 | 231 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 49.68 | 48.81 | 50.63 |
| Only index persons | 48.07 | 47.96 | 48.24 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 100 | 65 | 35 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 51.87 | 47.92 | 59.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPERALI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERALI | 2.001 [1.3, 3.08] | 0.002 |
| Birth year | 0.997 [0.99, 1.01] | 0.458 |
During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 272 females with E4_HYPERALI died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPERALI | 3.536 [2.12, 5.89] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 172 males with E4_HYPERALI died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPERALI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.189% | 0.859% |
| 5 | 1.144% | 4.315% |
| 10 | 3.079% | 10.302% |
| 15 | 5.724% | 18.891% |
| 20 | 9.954% | 29.966% |
Relationships between endpoints
↥Index endpoint: E4_HYPERALI – Other hyperalimentation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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