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This is a non-core endpoint: only basic statistics are computed.

Disorders of glycoprotein metabolism

E4_GLYCOPROT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E77
  • Cause of death: ICD-10 E77

2 out of 7 registries used, show all original rules.

40

4. Check minimum number of events

None

40

5. Include endpoints

40

6. Filter based on genotype QC (FinnGen only)

36

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Perturbationes metabolismi glycoproteinorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 490 243 246
Only index persons 390 191 199
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 39.76 40.27 39.07
Only index persons 38.47 38.07 38.86

-FinnGen-

Key figures

All Female Male
Number of individuals 36 21 15
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 52.05 52.52 51.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint E4_GLYCOPROT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_GLYCOPROT 5.737 [3.32, 9.92] < 0.001
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 195 males with E4_GLYCOPROT died.

Mortality risk

Mortality risk for people of age

years, who have E4_GLYCOPROT.

N-year risk Females Males
1 No data 0.985%
5 No data 5.653%
10 No data 14.629%
15 No data 26.381%
20 No data 40.026%

Relationships between endpoints

Index endpoint: E4_GLYCOPROT – Disorders of glycoprotein metabolism

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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