Gilbert syndrome: An autosomal recessive inherited disorder characterized by unconjugated hyperbilirubinemia, resulting in harmless intermittent jaundice.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
244 |
4. Check minimum number of eventsNone |
244 |
5. Include endpointsNone |
244 |
6. Filter based on genotype QC (FinnGen only) |
229 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E80
Name in latin
Syndroma Gilbert
Similar endpoints
↥List of similar endpoints to
Gilbert syndrome
based on the number of shared cases.
Similar with more cases:
- Disorders of porphyrin and bilirubin metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2080 | 758 | 1310 |
| Only index persons | 1976 | 732 | 1244 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.04 |
| Only index persons | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 35.03 | 37.47 | 33.51 |
| Only index persons | 34.37 | 36.95 | 32.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 229 | 98 | 131 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.07 |
| Median age at first event (years) | 41.17 | 39.05 | 42.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_GILBERT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GILBERT | 1.128 [0.89, 1.43] | 0.317 |
| Birth year | 0.984 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 100 out of 970 males with E4_GILBERT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GILBERT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.198% |
| 5 | No data | 1.228% |
| 10 | No data | 3.072% |
| 15 | No data | 5.6% |
| 20 | No data | 9.732% |
Relationships between endpoints
↥Index endpoint: E4_GILBERT – Gilbert syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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