No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
742 |
4. Check minimum number of eventsNone |
742 |
5. Include endpointsNone |
742 |
6. Filter based on genotype QC (FinnGen only) |
717 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced cataract
based on the number of shared cases.
Similar with more cases:
- Other cataract
- Disorders of lens
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4232 | 2397 | 1803 |
| Only index persons | 3685 | 2140 | 1545 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.05 |
| Only index persons | 0.07 | 0.08 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 56.28 | 56.55 | 55.83 |
| Only index persons | 55.90 | 56.26 | 55.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 717 | 426 | 291 |
| Unadjusted period prevalence (%) | 0.16 | 0.17 | 0.15 |
| Median age at first event (years) | 55.20 | 54.51 | 56.22 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_CATAR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_CATAR | 3.266 [2.86, 3.73] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.061 |
During the follow-up period (1.1.1998 — 31.12.2019), 634 out of 2151 females with DRUGADVERS_CATAR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_CATAR | 3.542 [3.09, 4.06] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 578 out of 1606 males with DRUGADVERS_CATAR died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_CATAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.22% | 0.562% |
| 5 | 2.003% | 3.4% |
| 10 | 4.599% | 9.293% |
| 15 | 8.461% | 17.053% |
| 20 | 13.692% | 27.482% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_CATAR – Drug-induced cataract
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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