Chronic myeloid leukaemia [CML], BCR/ABL-positive

CML

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C92.1
  • Hospital discharge: ICD-9 2051
  • Cause of death: ICD-10 C92.1
  • Cause of death: ICD-9 2051

2 out of 7 registries used, show all original rules.

306

4. Check minimum number of events

None

306

5. Include endpoints

None

306

6. Filter based on genotype QC (FinnGen only)

289

Control definitions (FinnGen only)

Control exclude MYELOPROF

Extra metadata

First used in FinnGen datafreeze DF2, additional

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2730 1222 1459
Only index persons 1748 801 947
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 61.57 61.90 61.03
Only index persons 59.17 59.30 59.06

-FinnGen-

Key figures

All Female Male
Number of individuals 289 139 150
Unadjusted period prevalence (%) 0.07 0.05 0.08
Median age at first event (years) 58.35 57.64 59.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CML and mortality.

Females

Parameter HR [95% CI] p-value
CML 4.426 [3.35, 5.85] < 0.001
Birth year 0.998 [0.99, 1.01] 0.636

During the follow-up period (1.1.1998 — 31.12.2019), 322 out of 808 females with CML died.

Males

Parameter HR [95% CI] p-value
CML 3.628 [2.8, 4.71] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 423 out of 944 males with CML died.

Mortality risk

Mortality risk for people of age

years, who have CML.

N-year risk Females Males
1 0.525% 0.565%
5 2.993% 4.051%
10 7.101% 9.458%
15 13.164% 18.283%
20 22.051% 29.576%

Relationships between endpoints

Index endpoint: CML – Chronic myeloid leukaemia [CML], BCR/ABL-positive

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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