No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2551 |
4. Check minimum number of eventsNone |
2551 |
5. Include endpointsNone |
2551 |
6. Filter based on genotype QC (FinnGen only) |
2457 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K50
Name in latin
Morbus Crohn intestini tenuis
Similar endpoints
↥List of similar endpoints to
Crohn's disease of small intestine
based on the number of shared cases.
Similar with more cases:
- Crohn disease
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14329 | 7428 | 6841 |
| Only index persons | 13748 | 7172 | 6576 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.21 | 0.19 |
| Only index persons | 0.26 | 0.26 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 41.93 | 41.13 | 42.78 |
| Only index persons | 41.18 | 40.37 | 42.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2457 | 1408 | 1049 |
| Unadjusted period prevalence (%) | 0.54 | 0.55 | 0.53 |
| Median age at first event (years) | 43.91 | 41.32 | 47.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHRONSMALL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONSMALL | 1.57 [1.37, 1.79] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.104 |
During the follow-up period (1.1.1998 — 31.12.2019), 611 out of 6408 females with CHRONSMALL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONSMALL | 1.399 [1.24, 1.58] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 700 out of 5914 males with CHRONSMALL died.
Mortality risk
Mortality risk for people of age
years, who have CHRONSMALL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.143% | 0.206% |
| 5 | 0.879% | 1.518% |
| 10 | 2.039% | 3.892% |
| 15 | 4.114% | 6.981% |
| 20 | 7.229% | 12.134% |
Relationships between endpoints
↥Index endpoint: CHRONSMALL – Crohn's disease of small intestine
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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