ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2649 |
4. Check minimum number of eventsNone |
2649 |
5. Include endpointsNone |
2649 |
6. Filter based on genotype QC (FinnGen only) |
2553 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K50
Name in latin
Alis morbus Crohn specificatus
Similar endpoints
↥List of similar endpoints to
Other Crohn's disease
based on the number of shared cases.
Similar with more cases:
- Crohn disease
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14492 | 7232 | 7199 |
| Only index persons | 13958 | 7026 | 6932 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.21 | 0.20 |
| Only index persons | 0.26 | 0.26 | 0.26 |
| Median age at first event (years) | |||
| Whole population | 38.98 | 39.26 | 38.69 |
| Only index persons | 38.52 | 38.89 | 38.15 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2553 | 1424 | 1129 |
| Unadjusted period prevalence (%) | 0.56 | 0.56 | 0.57 |
| Median age at first event (years) | 41.23 | 39.88 | 42.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHRONOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONOTH | 1.589 [1.4, 1.81] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.559 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 6461 females with CHRONOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONOTH | 1.474 [1.31, 1.66] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 669 out of 6316 males with CHRONOTH died.
Mortality risk
Mortality risk for people of age
years, who have CHRONOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.153% | 0.313% |
| 5 | 0.962% | 1.599% |
| 10 | 2.64% | 4.085% |
| 15 | 4.871% | 7.282% |
| 20 | 8.383% | 12.779% |
Relationships between endpoints
↥Index endpoint: CHRONOTH – Other Crohn's disease
GWS hits: 13
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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