Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2452 |
4. Check minimum number of eventsNone |
2452 |
5. Include endpointsNone |
2452 |
6. Filter based on genotype QC (FinnGen only) |
2364 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K50
Name in latin
Morbus Crohn non specificatus
Similar endpoints
↥List of similar endpoints to
Crohn's disease NAS
based on the number of shared cases.
Similar with more cases:
- Crohn disease
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15650 | 8081 | 7511 |
| Only index persons | 14606 | 7608 | 6998 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.23 | 0.21 |
| Only index persons | 0.27 | 0.28 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 42.77 | 43.01 | 42.39 |
| Only index persons | 41.39 | 41.80 | 40.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2364 | 1309 | 1055 |
| Unadjusted period prevalence (%) | 0.52 | 0.51 | 0.53 |
| Median age at first event (years) | 44.22 | 42.10 | 46.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHRONNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONNAS | 2.009 [1.78, 2.27] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.073 |
During the follow-up period (1.1.1998 — 31.12.2019), 1045 out of 7289 females with CHRONNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONNAS | 1.914 [1.68, 2.18] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1096 out of 6704 males with CHRONNAS died.
Mortality risk
Mortality risk for people of age
years, who have CHRONNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.195% | 0.372% |
| 5 | 1.175% | 2.221% |
| 10 | 3.009% | 5.14% |
| 15 | 5.486% | 9.502% |
| 20 | 9.612% | 16.21% |
Relationships between endpoints
↥Index endpoint: CHRONNAS – Crohn's disease NAS
GWS hits: 9
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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