Crohn's colitis: Crohn's disease affecting the colon.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1940 |
4. Check minimum number of eventsNone |
1940 |
5. Include endpointsNone |
1940 |
6. Filter based on genotype QC (FinnGen only) |
1870 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K50
Name in latin
Colitis regionalis
Similar endpoints
↥List of similar endpoints to
Crohn's disease of large intestine
based on the number of shared cases.
Similar with more cases:
- Crohn disease
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11142 | 5575 | 5526 |
| Only index persons | 10570 | 5321 | 5249 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.16 | 0.15 |
| Only index persons | 0.20 | 0.20 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 40.90 | 41.88 | 39.80 |
| Only index persons | 40.05 | 41.07 | 39.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1870 | 1053 | 817 |
| Unadjusted period prevalence (%) | 0.41 | 0.41 | 0.41 |
| Median age at first event (years) | 42.48 | 41.10 | 44.27 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHRONLARGE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONLARGE | 1.588 [1.4, 1.8] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.373 |
During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 4996 females with CHRONLARGE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONLARGE | 1.464 [1.3, 1.64] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.042 |
During the follow-up period (1.1.1998 — 31.12.2019), 652 out of 4962 males with CHRONLARGE died.
Mortality risk
Mortality risk for people of age
years, who have CHRONLARGE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.185% | 0.252% |
| 5 | 1.088% | 1.743% |
| 10 | 2.417% | 4.323% |
| 15 | 4.304% | 8.995% |
| 20 | 7.781% | 15.209% |
Relationships between endpoints
↥Index endpoint: CHRONLARGE – Crohn's disease of large intestine
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data