No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<16 Registry filters:
2 out of 7 registries used, show all original rules. |
7484 |
4. Check minimum number of eventsNone |
7484 |
5. Include endpointsNone |
7484 |
6. Filter based on genotype QC (FinnGen only) |
7128 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
First used in FinnGen datafreeze
DF2
Childhood allergy (age < 16)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 218831 | 92626 | 126170 |
| Only index persons | 168254 | 71699 | 96555 |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.16 | 2.65 | 3.53 |
| Only index persons | 3.24 | 2.64 | 3.69 |
| Median age at first event (years) | |||
| Whole population | 4.95 | 5.31 | 4.69 |
| Only index persons | 6.16 | 6.57 | 5.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 7128 | 4459 | 2669 |
| Unadjusted period prevalence (%) | 1.60 | 1.75 | 1.34 |
| Median age at first event (years) | 8.32 | 8.64 | 7.79 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHILDHOOD_ALLERGY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHILDHOOD_ALLERGY | 1.18 [0.96, 1.45] | 0.119 |
| Birth year | 0.999 [0.99, 1.01] | 0.757 |
During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 77328 females with CHILDHOOD_ALLERGY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHILDHOOD_ALLERGY | 1.095 [0.97, 1.24] | 0.149 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 536 out of 105588 males with CHILDHOOD_ALLERGY died.
Mortality risk
Mortality risk for people of age
years, who have CHILDHOOD_ALLERGY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.125% | 0.212% |
| 5 | 0.681% | 1.387% |
| 10 | 1.887% | 3.63% |
| 15 | 3.624% | 6.746% |
| 20 | 6.102% | 11.533% |
Relationships between endpoints
↥Index endpoint: CHILDHOOD_ALLERGY – Childhood allergy (age < 16)
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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