No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D00-D09
Name in latin
Carcinoma in situ cervicis uteri
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ of skin
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ of skin
- In situ neoplasms
- In situ neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23551 | 13334 | 10135 |
| Only index persons | 22087 | 12633 | 9454 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.34 | 0.38 | 0.28 |
| Only index persons | 0.42 | 0.46 | 0.36 |
| Median age at first event (years) | |||
| Whole population | 78.17 | 79.15 | 76.91 |
| Only index persons | 78.09 | 79.01 | 76.87 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2315 | 1217 | 1098 |
| Unadjusted period prevalence (%) | 0.51 | 0.48 | 0.55 |
| Median age at first event (years) | 73.92 | 73.47 | 74.42 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_SKIN_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_SKIN_EXALLC | 0.987 [0.88, 1.1] | 0.817 |
| Birth year | 0.992 [0.98, 1.0] | 0.056 |
During the follow-up period (1.1.1998 — 31.12.2019), 3413 out of 10552 females with CD2_INSITU_SKIN_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_SKIN_EXALLC | 1.13 [0.98, 1.3] | 0.09 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2727 out of 7678 males with CD2_INSITU_SKIN_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have CD2_INSITU_SKIN_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.104% | 0.176% |
| 5 | 0.583% | 1.22% |
| 10 | 1.301% | 3.321% |
| 15 | 2.481% | 6.212% |
| 20 | 4.533% | 10.461% |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_SKIN_EXALLC – Carcinoma in situ of skin
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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