No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00-D09
Name in latin
Melanoma in situ
Similar endpoints
↥List of similar endpoints to
Melanoma in situ
based on the number of shared cases.
Similar with more cases:
- Melanoma in situ
- In situ neoplasms
- In situ neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7222 | 3947 | 3251 |
| Only index persons | 6903 | 3818 | 3085 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.09 |
| Only index persons | 0.13 | 0.14 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 69.96 | 68.92 | 71.19 |
| Only index persons | 69.72 | 68.59 | 71.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1139 | 575 | 564 |
| Unadjusted period prevalence (%) | 0.25 | 0.23 | 0.28 |
| Median age at first event (years) | 68.77 | 66.27 | 71.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_MELANOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_MELANOMA_EXALLC | 0.995 [0.86, 1.15] | 0.943 |
| Birth year | 0.994 [0.99, 1.0] | 0.188 |
During the follow-up period (1.1.1998 — 31.12.2019), 627 out of 3279 females with CD2_INSITU_MELANOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_MELANOMA_EXALLC | 0.946 [0.8, 1.12] | 0.508 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 2656 males with CD2_INSITU_MELANOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have CD2_INSITU_MELANOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.173% |
| 5 | 0.517% | 0.981% |
| 10 | 1.435% | 2.39% |
| 15 | 2.698% | 4.565% |
| 20 | 4.845% | 7.94% |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_MELANOMA_EXALLC – Melanoma in situ
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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