Carcinoma in situ of cervix uteri

CD2_INSITU_CERVIX_UTERI_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

  • not C3_CERVIX_UTERI
-

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D06
  • Cause of death: ICD-10 D06
  • Cancer registry: Topography ICD-O-3 C53
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF9
Parent code in ICD-10 D00-D09
Name in latin Carcinoma in situ vaginae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5402 5402 -
Only index persons 5151 5151 -
Unadjusted period prevalence (%)
Whole population 0.15 0.15 -
Only index persons 0.19 0.19 -
Median age at first event (years)
Whole population - 36.09 -
Only index persons - 35.80 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3334 3334 -
Unadjusted period prevalence (%) 1.31 1.31 -
Median age at first event (years) 35.48 35.48 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_CERVIX_UTERI_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
CD2_INSITU_CERVIX_UTERI_EXALLC 1.416 [1.21, 1.65] < 0.001
Birth year 0.994 [0.99, 1.0] 0.175

During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 3908 females with CD2_INSITU_CERVIX_UTERI_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_CERVIX_UTERI_EXALLC.

N-year risk Females Males
1 0.151% No data
5 0.802% No data
10 1.94% No data
15 3.761% No data
20 6.487% No data

Relationships between endpoints

Index endpoint: CD2_INSITU_CERVIX_UTERI_EXALLC – Carcinoma in situ of cervix uteri

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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