Carcinoma in situ of breast, intraductal

CD2_INSITU_BREAST_INTRADUCTAL_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D05.1&
  • Cause of death: ICD-10 D05.1&

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D05
Name in latin Carcinoma in situ intraductale mammae

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 13450 13450 -
Only index persons 13149 13149 -
Unadjusted period prevalence (%)
Whole population 0.39 0.39 -
Only index persons 0.48 0.48 -
Median age at first event (years)
Whole population - 60.44 -
Only index persons - 60.43 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2651 2651 -
Unadjusted period prevalence (%) 1.04 1.04 -
Median age at first event (years) 60.21 60.21 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_BREAST_INTRADUCTAL_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
CD2_INSITU_BREAST_INTRADUCTAL_EXALLC 1.095 [0.98, 1.22] 0.103
Birth year 0.994 [0.98, 1.0] 0.148

During the follow-up period (1.1.1998 — 31.12.2019), 1321 out of 11719 females with CD2_INSITU_BREAST_INTRADUCTAL_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_BREAST_INTRADUCTAL_EXALLC.

N-year risk Females Males
1 0.11% No data
5 0.651% No data
10 1.528% No data
15 2.962% No data
20 4.977% No data

Relationships between endpoints

Index endpoint: CD2_INSITU_BREAST_INTRADUCTAL_EXALLC – Carcinoma in situ of breast, intraductal

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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