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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_BREAST_EXALLC for full statistics.

Carcinoma in situ of breast

DOID EFO Endpoint Browser

CD2_INSITU_BREAST

breast ductal carcinoma in situ: A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

  • not C3_BREAST
244477

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D05
  • Cause of death: ICD-10 — D05
  • Cancer registry: Topography ICD-O-3 — C50
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 2

3 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

124

6. Filter based on genotype QC (FinnGen only)

116

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF9
Parent code in ICD-10 D00-D09
Name in latin Carcinoma in situ vulvae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 116 116 -
Unadjusted period prevalence (%) 0.05 0.05 -
Median age at first event (years) 59.91 59.91 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_BREAST – Carcinoma in situ of breast

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).