No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D09
Similar endpoints
↥List of similar endpoints to
Carcinoma in situ, bladder
based on the number of shared cases.
Similar with more cases:
- Carcinoma in situ, bladder
- Carcinoma in situ of other and unspecified sites
- Carcinoma in situ of other and unspecified sites
- In situ neoplasms
- In situ neoplasms
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4595 | 913 | 3669 |
| Only index persons | 4430 | 880 | 3550 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.03 | 0.10 |
| Only index persons | 0.12 | 0.03 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 72.42 | 72.37 | 72.44 |
| Only index persons | 72.33 | 72.15 | 72.38 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 956 | 174 | 782 |
| Unadjusted period prevalence (%) | 0.33 | 0.07 | 0.39 |
| Median age at first event (years) | 71.53 | 68.50 | 72.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_INSITU_BLADDER_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_BLADDER_EXALLC | 1.104 [0.82, 1.49] | 0.513 |
| Birth year | 0.999 [0.99, 1.01] | 0.751 |
During the follow-up period (1.1.1998 — 31.12.2019), 123 out of 763 females with CD2_INSITU_BLADDER_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_INSITU_BLADDER_EXALLC | 0.965 [0.79, 1.18] | 0.735 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 517 out of 3037 males with CD2_INSITU_BLADDER_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have CD2_INSITU_BLADDER_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.173% |
| 5 | 0.776% | 0.998% |
| 10 | 1.886% | 2.552% |
| 15 | 3.643% | 4.903% |
| 20 | 6.21% | 8.331% |
Relationships between endpoints
↥Index endpoint: CD2_INSITU_BLADDER_EXALLC – Carcinoma in situ, bladder
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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