thyroid carcinoma: A carcinoma arising from the thyroid gland. It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1088 |
4. Check minimum number of eventsNone |
1088 |
5. Include endpointsNone |
1088 |
6. Filter based on genotype QC (FinnGen only) |
1067 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum glandulae thyreoideae
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of thyroid gland
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of thyroid gland
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7907 | 6229 | 1639 |
| Only index persons | 7326 | 5875 | 1451 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.18 | 0.05 |
| Only index persons | 0.18 | 0.22 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 51.68 | 50.47 | 56.14 |
| Only index persons | 50.64 | 49.65 | 54.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1067 | 829 | 238 |
| Unadjusted period prevalence (%) | 0.28 | 0.33 | 0.12 |
| Median age at first event (years) | 51.88 | 49.75 | 59.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_THYROID and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 0.943 [0.83, 1.06] | 0.343 |
| Birth year | 0.993 [0.98, 1.0] | 0.136 |
During the follow-up period (1.1.1998 — 31.12.2019), 416 out of 3924 females with CD2_BENIGN_THYROID died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_THYROID | 1.195 [1.01, 1.42] | 0.042 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 240 out of 1134 males with CD2_BENIGN_THYROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_THYROID.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.091% | 0.186% |
| 5 | 0.58% | 1.233% |
| 10 | 1.361% | 3.105% |
| 15 | 2.586% | 5.841% |
| 20 | 4.419% | 10.295% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_THYROID – Benign neoplasm of thyroid gland
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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