skin neoplasm: A benign or malignant tumor involving the skin. Representative examples of benign skin neoplasms include the benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma. Representative examples of malignant skin neoplasms include basal cell carcinoma, squamous cell carcinoma, melanoma, and Kaposi sarcoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
14292 |
4. Check minimum number of eventsNone |
14292 |
5. Include endpoints |
15669 |
6. Filter based on genotype QC (FinnGen only) |
15186 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Alia neoplasmata benigna cutis
Similar endpoints
↥List of similar endpoints to
Other benign neoplasms of skin
based on the number of shared cases.
Similar with more cases:
- Other benign neoplasms of skin
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 127839 | 74189 | 53046 |
| Only index persons | 116814 | 69212 | 47602 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.85 | 2.12 | 1.48 |
| Only index persons | 2.25 | 2.54 | 1.82 |
| Median age at first event (years) | |||
| Whole population | 56.85 | 56.26 | 57.61 |
| Only index persons | 56.16 | 55.65 | 56.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 15186 | 9037 | 6149 |
| Unadjusted period prevalence (%) | 3.36 | 3.55 | 3.09 |
| Median age at first event (years) | 57.70 | 54.59 | 62.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_SKIN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SKIN | 0.934 [0.86, 1.01] | 0.087 |
| Birth year | 0.996 [0.99, 1.0] | 0.294 |
During the follow-up period (1.1.1998 — 31.12.2019), 10043 out of 57649 females with CD2_BENIGN_SKIN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_SKIN | 1.02 [0.94, 1.11] | 0.65 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 9868 out of 40928 males with CD2_BENIGN_SKIN died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_SKIN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.077% | 0.187% |
| 5 | 0.534% | 1.157% |
| 10 | 1.364% | 2.828% |
| 15 | 2.697% | 5.584% |
| 20 | 4.861% | 10.007% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_SKIN – Other benign neoplasms of skin
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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